Investigating the Antimicrobial Effect of Loranthus europeaus Leaf Hydroalcoholic Extract Against Methicillin-Resistant Staphylococcus aureus

Abstract

Introduction: Staphylococcus aureus is one of the important factors that causes hospital infections. In recent years, the emergence of antibiotic resistance has become widespread. Methicillin-resistant S. aureus (MRSA) infection is caused by a type of staphylococcus bacteria that is resistant to many antibiotics. The use of medicinal plants for the treatment of various diseases has increased recently. Hence, we decided to evaluate the antimicrobial effect of Loranthus europaeus leaf hydroalcoholic extract against methicillin-resistant S. aureus. Methods: The leaves of L. europeaus were collected from Khorramabad in Lorestan province. After drying the leaves, a hydroalcoholic extract of this plant was prepared. Finally, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of the hydroalcoholic extract of L. europeaus were measured by the CLSI microdilution method. Results: Based on the results, the MIC and MBC values for the hydroalcoholic extract of the leaves of L. europaeus were 6.13 μg/mL and 98 μg/mL for MRSA, respectively. Conclusion: Our results showed that MRSA clinical strain was sensitive to the hydroalcoholic extract of L. europaeus. Therefore, this extract can be proposed as a good solution for routine antibiotics.

Keywords: Medicinal plants, Methicillin, Staphylococcus aureus, Loranthus europeaus, Antimicrobial