Journal of Biochemicals and Phytomedicine 2958-8561 4 2 2025 12 15 Development of A Daily Oral Hygiene Product with Zinc Sulfate 26 33 10.34172/jbp.2025.14 EN Ihor Hrynovets https://orcid.org/0000-0003-1727-3526 Mariana Storozhynska https://orcid.org/0009-0002-5299-8960 Roman Lysiuk https://orcid.org/0000-0003-0961-2970 Journal Article 10.34172/jbp.2025.14 2025 01 29 2025 06 03 Introduction: Proper oral care is essential for overall health. The effectiveness of daily hygiene depends on its thoroughness and personalization. Without regular cleaning, the oral cavity accumulates pathogenic microbes, damaging soft tissues and hard tooth structures, compromising bodily integrity. This study aimed to evaluate oral hygiene products and develop an effective daily-use preventive rinse. Methods: We reviewed studies on dental diseases and hygiene products via PubMed, Scopus, and Web of Science. The rinse was developed considering ingredient properties and regulatory guidelines. Microbiological safety, organoleptic, and physicochemical properties were tested. Results: Mouthwashes enhance oral hygiene by mechanically cleaning teeth, gums, and interdental spaces, removing debris and pathogens. Regular use prevents disease and improves tissue blood flow. Based on existing evidence, we formulated a rinse containing zinc sulfate (inhibits plaque and calculus) and clove oil (antimicrobial and antioxidant). A scalable production process was designed. Quality was assured through organoleptic, physicochemical, and microbiological tests. Conclusion: The developed antimicrobial and anti-inflammatory rinse is suitable for daily use, improving interdental cleaning.